2024 AK Visiting Lecture Series 02

Provided by: MGH Center for Faculty Development & Mass General Brigham

2024 AK Visiting Lecture Series 02
“Role of branched-chain amino acid catabolism in healthy and injured kidney”

The Anne Klibanski Visiting Lecture Series was created to support and advance the careers of women. These lectures offer the opportunity for women faculty from outside institutions that have hosted Anne Klibanski Scholars to present on their expertise, either alone or in tandem with an Anne Klibanski Scholar.

Learning Objectives:
Upon completion of this activity, participants were able to:

• Understand the metabolic pathways used to generate ATP in healthy proximal tubule cells.
• Understand how these pathways change in the setting of AKI.
• Understand how the branched-chain amino acid (BCAA) catabolic pathway may be regulated.
• Understand the cellular and physiological consequences of altered BCAA catabolism.

Presenter:
Sian E. Piret, PhD, Assistant Professor, Division of Nephrology and Hypertension Renaissance School of Medicine, Stony Brook University

Dr. Piret is currently an Assistant Professor of Medicine in the Division of Nephrology and Hypertension in the Department of Medicine at Stony Brook University. She graduated with a Master of Biochemistry degree (MBiochem) from the University of Oxford in 2003 and went on to gain her DPhil (PhD) with Professor Rajesh Thakker at the University of Oxford. Her thesis focused on the role of uromodulin in the thick ascending limb of the nephron, and elucidated mechanisms by which uromodulin mutations cause the monogenic disorder autosomal dominant tubulointerstitial kidney disease. She then stayed in Prof. Thakker’s lab to undertake post-doctoral research, broadening her studies to include mechanisms of the inherited kidney stone disorder Dent’s disease, as well as disorders of calcium homeostasis, including those due to mutations in the calcium-sensing receptor pathway. Dr. Piret joined Stony Brook University in 2017, initially studying the role of Krüppel-like factor transcription factors in AKI and CKD as a postdoctoral Research Scientist and Research Assistant Professor, before becoming Assistant Professor in 2020. Her current research focuses on mechanisms of injury and repair in AKI, and the transition to CKD, including proximal tubule cellular metabolism. She is a previous recipient of a Joseph V. Bonventre Research Scholar Award from the ASN, and is a current AHA Career Development Award and NIDDK R01 grant holder.

Target Audience: This activity is intended for faculty and faculty trainees.
Course Director: Darshan H. Mehta, MD, MPH, Office for Well-Being; Assistant Professor of Medicine, Harvard Medical School

ACCREDITATION

In support of improving patient care, Mass General Brigham is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Mass General Brigham designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Education (CE) credits for psychologists are provided through the co-sponsoring of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibly for the content of the programs. 1 Continuing Education (CE) credit is awarded.